Dengue Virus
According to World Health Organization, there are 50 million cases of Dengue infection worldwide every year. The infection is an epidemic in over 100 countries, especially in subtropical regions. The virus belongs to the avivirus group and is transmitted by Aceder mosquitoes.
The primary and secondary infections of dengue virus exhibit dierent clinical proles. Primary Dengue infection is the most common type of dengue illness. It is associated with mild to high fever, head- ache, muscle pain, and skin rash. Secondary infection is known as Dengue Hemorrhagic Fever (DHF) or Dengue Shock Syndrome, and often results in high fever and, in many cases, hemorrhagic events and circula-
tory failure. The fatality rate in patients with Dengue Shock Syndrome can be as high as 44%.
Diagnosis
Serological studies demonstrate that in primary Dengue viral infections, IgM antibodies are detect-able by the 5th day of infection and remains detectable for 30 – 60 days. Whereas IgG antibodies appear by the 14th day of infection and persist for life.
In contrast, during secondary infections, specic IgG and IgM levels signicantly increase by day 1- 2 and day 20 after infection, respectively. Thus, dierent proles of humoral immune responses in primary and secondary dengue viral infections can be used for dierential diagnosis, which is of clinical signicance in predicting progression and prognosis of the disease.
Artron One-Step
| Catalogue | Product | Detection | Sample |
| A03-08 | Dengue Virus IgG/IgM Test Kit | Dengue Virus IgG/IgM Antibody | S / P / WB |
| A03-22 | Dengue NS1 Test Kit | Dengue NS1 Antigen | S / P / WB |
| A03-24 | Dengue Combo | Dengue Virus IgG/IgM Antibody & NS1 Antigen | S / P / WB |
NS 1
Dengue NS1 antigen is a highly conserved glycoprotein found in high concentrations within dengue-infected patients during the early clinical phase of the disease. NS1 antigen is detectable for the period of 9 days after the onset of infection and it can be detected in both serum/plasma or whole blood. Artron offers the One-Step Dengue NS1 Antigen Test Kit to detect presence of NS1 antigen, for quick and reliable detection of the disease. The Dengue NS1 Antigen Test kit is available in both strip and cassette format, or as a combo with the Dengue IgG/IgM Test kit.
Specificity: 93.9% | Sensitivity: 98.2%
Specicity: 92.7%
Sensitivity: 91.0%
Accuracy: 92.0%
IgG / IgM
Available in strip and cassette format, Artron Dengue IgG/IgM Antibody Test is able to detect all 4 Dengue serotypes since it uses a unique mixture of highly puried proteins. The test is intended for professional use to diagnose Dengue viral infections and to help to dierentiate between a primary and secondary dengue infection.
IgG/IgM NS1 Combo
A convenient 2 in 1 test that houses both the IgG/IgM and the NS1 test in one combo cassette. It is available in Cassette format only for whole blood samples.
